Study of the host specificity of PB1-F2-associated virulence

Joëlle Mettier, Daniel Marc, Laura Sedano, Bruno Da Costa, Christophe Chevalier & Ronan Le Goffic
Influenza A viruses cause important diseases in both human and animal. The PB1-F2 protein is a virulence factor expressed by some influenza viruses. Its deleterious action for the infected host is mostly described in mammals, while the available information is scarce in avian hosts. In this work, we compared the effects of PB1-F2 in avian and mammalian hosts by taking advantage of the zoonotic capabilities of an avian H7N1 virus. In vitro, the H7N1 virus...
1 citation reported since publication in 2021.
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