Network pharmacology-based analysis in determining the mechanisms of Huoxin pill in protecting against myocardial infarction

Jia He, Da Wo, En Ma, Qing Wang, Jinxiao Chen, Jun Peng, Weidong Zhu & Dan-ni Ren
Huoxin pill (HXP) is a commonly used TCM prescription for treatment of cardiovascular diseases. However, its mechanism in protecting against myocardial infarction (MI) remains unknown. We performed a network pharmacology analysis to explore the bioactive ingredients, therapeutic effects, and mechanisms of HXP in protecting against MI. HPLC was used to identify major bioactive compounds, and overlap with MI target genes were visualised. 10-Week old C57BL/6 mice were randomly assigned as: Sham-operated control, MI + Phosphate...
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