Design and evaluation of glutathione responsive glycosylated camptothecin nanosupramolecular prodrug

Wenhua Li, Zhong Chen, Xiaoying Liu, Mingming Lian, Haisheng Peng & Changmei Zhang
A novel tumor-targeted glutathione responsive Glycosylated-Camptothecin nanosupramolecular prodrug (CPT-GL NSp) was designed and fabricated via a disulfide bond. The effects of glycoligand with different polarities on solubility, self-assembly, stability, cellular uptake, and glutathione responsive cleaving were explored, and an optimal glycosylated ligand was selected for nanosupramolecular prodrug. It has been found that CPT-GL NSp exhibited higher drug loading than traditional nanoparticles. Among of which maltose modified NSp had the strongest anti-tumor effects than that of...
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