An approach to assessing the contribution of the high LET effect in strategies for Auger endoradiotherapy

Pavel Lobachevsky, Colin Skene, Laura Munforte, Andrea Smith, Jonathan White & Roger F. Martin
Purpose: The interest in exploiting Auger emitters in cancer therapy stems from their high linear energy transfer (LET)-type radiation damage to DNA. However, the design of Auger-emitter labeled vehicles that target the Auger cascade specifically to the DNA of tumour cells is challenging. Here we suggest a possible approach to evaluate tumour-targeting Auger-labeled conjugates by assessing the impact of a radioprotector known to be effective in protecting from low LET radiation, but not high LET...
1 citation reported since publication in 2021.
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