Nucleoporin 160 (NUP160) inhibition alleviates diabetic nephropathy by activating autophagy

Jiayong Xie, Ying Yuan, Gang Yao, Zhi Chen, Wenjuan Yu & Qiang Zhu
Diabetic nephropathy (DN) is the leading cause of end-stage renal disease worldwide. Autophagy was reported to be related to the pathogenesis of DN. This research investigated the function of the Nucleoporin 160 (Nup160) gene in regulating autophagy in DN. A mouse model of DN was established through an intraperitoneal injection of streptozotocin (STZ). Normal rat kidney tubular epithelial cells (NRK-52E) were treated with high glucose to induce DN in vitro. Real-time quantitative polymerase chain reaction...
1 citation reported since publication in 2021.
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