Quantitative proteomics reveals that dormancy-related proteins mediate the attenuation in mycobacterium strains

Hong Wang, Li Wan, Jiahui Shi, Tao Zhang, Huiming Zhu, Songhao Jiang, Shuhong Meng, Shujia Wu, Jinshuai Sun, Lei Chang, Liqun Zhang, Kanglin Wan, Jiaqi Yang, Xiuqin Zhao, Haican Liu, Yao Zhang, Erhei Dai & Ping Xu
Although members of the Mycobacterium tuberculosis complex (MTBC) exhibit high similarity, they are characterized by differences with respect to virulence, immune response, and transmissibility. To understand the virulence of these bacteria and identify potential novel therapeutic targets, we systemically investigated the total cell protein contents of virulent H37Rv, attenuated H37Ra, and avirulent M. bovis BCG vaccine strains at the log and stationary phases, based on tandem mass tag (TMT) quantitative proteomics. Data analysis revealed that...
1 citation reported since publication in 2021.
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