Urinary Metals and Maternal Circulating Extracellular Vesicle microRNA in the MADRES Pregnancy Cohort
Caitlin G Howe, Helen B Foley, Shohreh F Farzan, Thomas A Chavez, Mark Johnson, John D Meeker, Theresa M Bastain, Carmen J Marsit & Carrie V Breton
Background: Exposure to metals increases risk for pregnancy complications. Extracellular vesicle (EV) miRNA contribute to maternal-fetal communication and are dysregulated in pregnancy complications. However, metal impacts on maternal circulating EV miRNA during pregnancy are unknown. Our objective was to investigate the impact of multiple metal exposures on EV miRNA in maternal circulation during pregnancy in the MADRES Study. Methods: Associations between urinary concentrations of nine metals and 106 EV miRNA in maternal plasma during pregnancy...
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