M. tuberculosis CRISPR/Cas proteins are secreted virulence factors that trigger cellular immune responses

Jianjian Jiao, Nan Zheng, Wenjing Wei, Joy Fleming, Xingyun Wang, Zihui Li, Lili Zhang, Yi Liu, Zongde Zhang, Adong Shen, Li Chuanyou, Lijun Bi & Hongtai Zhang
The role of prokaryotic CRISPR/Cas system proteins as a defensive shield against invasive nucleic acids has been studied extensively. Non-canonical roles in pathogenesis involving intracellular targeting of certain virulence-associated endogenous mRNA have also been reported for some Type I and Type II CRISPR/Cas proteins, but no such roles have yet been established for Type III system proteins. Here, we demonstrate that M. tuberculosis (Type III-A system) CRISPR/Cas proteins Csm1, Csm3, Csm5, Csm6, and Cas6 are...
1 citation reported since publication in 2021.
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