Four new polyprenylated acylphloroglucinol derivatives from Hypericum beanii

Xin-Yue Suo, Xiao-Yu Liu, Xiao-Wei Liu, Xiao-Xiu Li, Ting-Ting Zhu, Teng-Fei Ji & Bo Liu
Two new polycyclic polyprenylated acylphloroglucinols (PPAPs), hyperbeanins P-Q (1-2), and two new biosynthetic precursors, hyperbeanins R-S (3-4), were isolated from Hypericum beanii, together with three known analogs (5-7). Compound 1 was one of type A PPAPs featured with unusual bicyclo[5.3.1]hendecane core. The structures of isolates were established by NMR spectroscopic methods, experimental electronic circular dichroism (ECD) spectra and comparisons with known compounds. Compounds 5 and 6 showed obvious hepatoprotective activity at 10 µM against paracetamol-induced...
1 citation reported since publication in 2021.
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