Vascular smooth muscle cell-derived hydrogen sulfide promotes atherosclerotic plaque stability via TFEB (transcription factor EB)-mediated autophagy

Zhenzhen Chen, Chenxi Ouyang, Haizeng Zhang, Yuanrui Gu, Yue Deng, Congkuo Du, Changting Cui, Shuangyue Li, Wenjie Wang, Wei Kong, Jingzhou Chen, Jun Cai & Bin Geng
Vascular smooth muscle cells (VSMCs) contribute to plaque stability. VSMCs are also a major source of CTH (cystathionine gamma-lyase)-hydrogen sulfide (H2S), a protective gasotransmitter in atherosclerosis. However, the role of VSMC endogenous CTH-H2S in pathogenesis of plaque stability and the mechanism are unknown. In human carotid plaques, CTH expression in ACTA2+ cells was dramatically downregulated in lesion areas in comparison to non-lesion areas. Intraplaque CTH expression was positively correlated with collagen content, whereas there was...
1 citation reported since publication in 2022.
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