LSD1 inhibitors from the roots of Pueraria lobata

Meng-Ru Tian, Kun Du, Yan-Le Zhi, Gui-Min Xue, Zhen-Zhu Zhao, Ying-Ying Si, Hui Chen, Yan-Jun Sun, Wei-Sheng Feng & Jin-Lian Ma
One new 6a,11a-dehydropterocarpan derivative, 6-O-methyl-anhydrotuberosin (1), one new 6a-hydroxypterocarpan, (6aR,11aR,11bR)-hydroxytuberosone (7), and seven known compounds including two 6a,11a-dehydropterocarpans (2 and 4), two coumestans (3 and 5), one isoflavonoid (6) and two other phenolic compounds (8 and 9) were isolated from the roots of Pueraria lobata. The structures of the isolated compounds were elucidated with spectroscopic and spectrometric methods (1 D and 2DNMR, HRESIMS). Compounds 1, 2, 4–5 showed potent LSD1 inhibitory activities with IC50 values...
1 citation reported since publication in 2022.
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