Two new cyclopentenone metabolites from Streptomyces sp. HU119

Wen-Shuai Song, Huan Qi, Shao-Yong Zhang, Han Wang, Cheng-Hong Zhang, Wen-Sheng Xiang, Ji-Dong Wang & Xiang-Jing Wang
Two previously undescribed cyclopentenone metabolites, (S)-2-(3-acetylamino-2-methyl)propyl-3-butyl-2-cyclopenten-1-one (1) and (S)-2-(3-acetylamino-2-ethyl)propyl-3-butyl-2-cyclopenten-1-one (2), were isolated from the fermentation broth of the strain Streptomyces sp. HU119. The structures of 1 and 2 were determined by the comprehensive spectroscopic analysis, including 1 D, 2 D NMR, MS spectral analysis and the comparison with data from the literature. The absolute configurations were elucidated by experimental and calculated optical rotations (OR). Compounds 1 and 2 displayed weak cytotoxic activity.
1 citation reported since publication in 2022.
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