Defective autophagy contributes to endometrial epithelial-mesenchymal transition in intrauterine adhesionsZhenhua Zhou, Huiyan Wang, Xiwen Zhang, Minmin Song, Simin Yao, Peipei Jiang, Dan Liu, Zhiyin Wang, Haining Lv, Ruotian Li, Ying Hong, Jianwu Dai, Yali Hu & Guangfeng Zhao
Intrauterine adhesions (IUA), characterized by endometrial fibrosis, is a common cause of uterine infertility. We previously demonstrated that partial epithelial-mesenchymal transition (EMT) and the loss of epithelial homeostasis play a vital role in the development of endometrial fibrosis. As a pro-survival strategy in maintaining cell and tissue homeostasis, macroautophagy/autophagy, conversely, may participate in this process. However, the role of autophagy in endometrial fibrosis remains unknown. Here, we demonstrated that autophagy is defective in endometria of...
1 citation reported since publication in 2022.
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