New and bioactive polyketides from Hawaiian marine-derived fungus Trichoderma sp. FM652

KH Ahammad Uz Zaman, Xiaohua Wu, Ariel M. Sarotti & Shugeng Cao
Two new sorbicillinoid derivatives (1 and 2), together with ten other related compounds (3–12) were isolated from a Hawaiian marine fungal strain Trichoderma sp. FM652. The structures of compounds 1 and 2, including the absolute configuration, were elucidated by extensive analysis of NMR spectroscopy, HRESIMS and electronic circular dichroism (ECD) data. Compounds 6–12 exhibited significant anti-proliferative activity against ovarian cancer cell line A2780, with the IC50 values ranging from 0.5 to 8.07 μM. Moreover, compounds...
1 citation reported since publication in 2022.
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