Nepetin reduces virulence factors expression by targeting ClpP against MRSA-induced pneumonia infection

Shisong Jing, Xinran Ren, Li Wang, Xiangri Kong, Xingye Wang, Xiren Chang, Xuerui Guo, Yan Shi, Jiyu Guan, Tiedong Wang, Bingmei Wang, Wu Song & Yicheng Zhao
The resistance of Staphylococcus aureus (S. aureus) to various antibiotics has increased dramatically due to the misuse of antibiotics, and thus the development of new anti-infective drugs with new targets is urgently needed to combat resistance. Caseinolytic peptidase P is a case in hydrolase that regulates the virulence level of S. aureus. Here, we found that nepetin, a small-molecule compound from traditional Chinese herbal flavonoids, effectively inhibits ClpP activity. Nepetin suppressed the virulence of S....
1 citation reported since publication in 2022.
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