Polysaccharides from laminaria japonica protect memory abilities and neurogenesis in mice after cranial irradiation through ameliorating neuroinflammation and collagen IV degradation

Siqin Zhang, Shaoyong Chen, Pian ao, Rong Cai, Wenqi Liu & Li Wei
Background: Radiation-induced brain injury (RIBI) is one of the most common long-term complications for patients with malignant brain tumors after radiotherapy. At present, there is no effective treatment for RIBI. Recent studies have also confirmed that polysaccharides from laminaria japonica (LJP) display potential neuroprotective function. However, its mechanisms of neuroprotection remain unclear. Aim: In this study, we aimed to explore effect and underlying mechanism of LJP on neurogenesis in radiation-induced brain injury mice. Methods: SPF...
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