The pathological involvement of spinal cord EphB2 in visceral sensitization in male rats

Tao Chen, Si Chen, Xuefeng Zheng, Yaofeng Zhu, Ziyun Huang, Linju Jia, Lisi OuYang & Wanlong Lei
Patients with post-traumatic stress disorder (PTSD) are usually at an increased risk for chronic disorders, such as irritable bowel syndrome (IBS), characterized by hyperalgesia and allodynia, but its subsequent effect on visceral hyperalgesia and the mechanism remain unclear. The present study employed single prolonged stress (SPS), a model of PTSD-pain comorbidity, behavioral evaluation, intrathecal drug delivery, immunohistochemistry, Western blotting, and RT-PCR techniques. When detecting visceral sensitivity, the score of the abdominal withdrawal reflex (AWR) induced...
1 citation reported since publication in 2022.
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