CFIm25 regulates human stem cell function independently of its role in mRNA alternative polyadenylation

Yi Ran, Shanshan Huang, Junjie Shi, Qiumin Feng, Yanhui Deng, Andy Peng Xiang & Chengguo Yao
It has recently been shown that CFIm25, a canonical mRNA 3’ processing factor, could play a variety of physiological roles through its molecular function in the regulation of mRNA alternative polyadenylation (APA). Here, we used CRISPR/Cas9-mediated gene editing approach in human embryonic stem cells (hESCs) for CFIm25, and obtained three gene knockdown/mutant cell lines. CFIm25 gene editing resulted in higher proliferation rate and impaired differentiation potential for hESCs, with these effects likely to be directly...
1 citation reported since publication in 2022.
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