Time-course full profiling of circulating miRNAs in neurologically deceased organ donors: a proof of concept study to understand the onset of the cytokine storm

Andrée-Anne Clément, Daphnée Lamarche, Marie-Hélène Masse, Cécilia Légaré, Lee-Hwa Tai, Laurence Fleury Deland, Marie-Claude Battista, Luigi Bouchard & Frédérick D’Aragon
Neurologically deceased organ donors (NDDs) generally display an immune response involving an intense production of pro-inflammatory cytokines referred to as the cytokine storm. The sudden surge of inflammatory mediators in circulation promotes tissue and organ damages and ultimately leads to poor transplant outcome. As microRNAs (miRNAs) are frequently proposed as key regulators of inflammation and are relatively stable in circulation, changes in their profiles could play a role in the onset of the cytokine storm...
1 citation reported since publication in 2022.
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