Two new sesquiterpenoids from plant endophytic fungus Flammulina velutipes

Jia-Yao Hu, Ting Yang, Jie Liu, Lei Xiao, Li-Bin Lin, Yi-Chao Li, Ming-Yue Ge, Ping Ji, Jian Xiao & Xiao-Ling Wang
Two new sesquiterpenoids, flammupin A (1) and flammupin B (2), along with two known compounds, enokipodin C (3) and 5,5'-dibuthoxy-2,2'-bifuran (4) were obtained from Flammulina velutipes, an endophytic fungus isolated from the roots of Caulophyllum robustum Maxim. The structures were elucidated by the combination of HR-ESI-MS, NMR, and ECD analyses. Compound 3 exhibited moderate to potent cytotoxicity against A549, HeLa, and SMMC-7721 cells with IC50 values ranged from 3.69 to 11.84 μM.
1 citation reported since publication in 2022.
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