A Composite Endpoint for Treatment Benefit According to Patient PreferenceYing Lu, Qian Zhao, Jiying Zou, Shiyan Yan, John S. Tamaresis, Lorene Nelson, Xin M. Tu, Jie Chen & Lu Tian
Complex disorders usually affect multiple symptom domains measured by several outcomes. The importance of these outcomes is often different among patients. Current approaches integrate multiple outcomes without considering patient preferences at the individual level. In this article, we propose a new composite Desirability of Outcome Ranking (DOOR) that integrates individual level ranking of outcome importance and define a winning probability measuring the overall treatment effect. Stratified randomization can be performed based on the participants’ baseline...
1 citation reported since publication in 2022.
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