Duloxetine overdose causes sympathomimetic and serotonin toxicity without major complications

Geoffrey K. Isbister, Robert Polanski, Joyce M. Cooper, Michael Keegan & Katherine Z. Isoardi
Duloxetine is a commonly used antidepressant that is a serotonin and norepinephrine reuptake inhibitor. We aimed to investigate the frequency and severity of clinical effects following duloxetine overdose. We undertook a retrospective review of duloxetine overdoses (>120 mg) admitted to two tertiary toxicology units between March 2007 and May 2021. Demographic information, details of ingestion (dose, co-ingestants), clinical effects, investigations (ECG parameters including QT interval), complications (coma [GCS < 9], serotonin toxicity, seizures and cardiovascular...
1 citation reported since publication in 2022.
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