Two new isoflavones from the roots of Sophora tonkinensis

Dao-Jun Chen, Shuang Yuan, Peng Zhang, Qiao An, Ji-Bin Zou, Chun-Mao Yuan, Li-Hua Zhao, Zhan-Xing Hu & Xiao-Jiang Hao
Two new isoflavones (1 and 2), as well as eight known ones were isolated from the roots of Sophora tonkinensis Gagnep. Compound 1 represents an unprecedented polymerization pattern constructed by isoflavone and cytisine. Their structures were elucidated by comprehensive spectroscopic data analysis, combined with ECD calculations. Compound 1 displayed significant anti-tobacco mosaic virus (TMV) activity compared with the positive control ningnanmycin. Moreover, compound 6 exhibited potent α-glucosidase inhibitory activity with IC50 value of 47.4 mg/L.
1 citation reported since publication in 2022.
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