Biomarkers of caspofungin resistance in Candida albicans isolates: A proteomic approach

Giuseppe Buda De Cesare, Ahmed Hafez, David Stead, Carlos Llorens & Carol A. Munro
Candida albicans is a clinically important polymorphic fungal pathogen that causes life-threatening invasive infections in immunocompromised patients. Antifungal therapy failure is a substantial clinical problem, due to the emergence of an increasing number of drug-resistant isolates. Caspofungin is a common antifungal drug, often used as first-line therapy that inhibits cell wall β-(1,3)-glucan synthesis. In this work, the cell surface of different echinocandin-resistant C. albicans clinical isolates was compared with sensitive isolates and their responses to...
1 citation reported since publication in 2022.
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