A multi-omics investigation into the mechanisms of hyper-virulence in Mycobacterium tuberculosisRahim Rajwani, Chala Galata, Annie Wing Tung Lee, Pui-Kin So, Kenneth Siu Sing Leung, Kingsley King Gee Tam, Sheeba Shehzad, Timothy Ting Leung Ng, Li Zhu, Hiu Yin Lao, Chloe Toi-Mei Chan, Jake Siu-Lun Leung, Lam-Kwong Lee, Kin Chung Wong, Wing Cheong Yam & Gilman Kit-Hang Siu
Clinical manifestations of tuberculosis range from asymptomatic infection to a life-threatening disease such as tuberculous meningitis (TBM). Recent studies showed that the spectrum of disease severity could be related to genetic diversity among clinical strains of Mycobacterium tuberculosis (Mtb). Certain strains are reported to preferentially invade the central nervous system, thus earning the label “hypervirulent strains”.However, specific genetic mutations that accounted for enhanced mycobacterial virulence are still unknown. We previously identified a set of 17...
1 citation reported since publication in 2022.
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