Design and characterization of gambogic acid-loaded mixed micelles system for enhanced oral bioavailability

Zhongcheng Ke, Jianjun Shi, Ziyang Cheng, Xiaoling Cheng, Huan Wang, Meng Wang, Jingjing Wu, Yinyu Sun & Changjiang Li
The aim of this study was to develop a gambogic acid-loaded mixed micelles (GA-M) system, using Kolliphor HS15 and lecithin, for enhancement of oral bioavailability. GA-M was prepared using the thin film hydration method, and particle size and zeta potential indexes were used to determine the optimized formulation was optimized with taking particle size, zeta potential as indexes. The optimal GA-M system had a mean particle size in the nanometer range (87.22 ± 0.68 nm)...
1 citation reported since publication in 2022.
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