Cyanidin chloride protects mice from methicillin-resistant Staphylococcus aureus-induced pneumonia by targeting Sortase A

Xin Su, Hangqian Yu, Xingye Wang, Chi Zhang, Heming Wang, Xiangri Kong, Yishen Qu, Yanhe Luan, Ying Meng, Jiyu Guan, Guangqi Song, Li Wang, Wu Song & Yicheng Zhao
Methicillin-resistant Staphylococcus aureus (MRSA) has been developing rapidly in recent years. It poses a severe peril to global health care, and the new strategies to against the MRSA is urgently needed. Sortase A (SrtA) regulates the anchoring of many surface proteins. Compounds repress Staphylococcus aureus (S. aureus) cysteine transpeptidase SrtA are considered adequate potent virulence inhibitors. Then, we describe the identification of an effective SrtA inhibitor, cyanidin chloride, a bioflavonoid compound isolated from various plants....
1 citation reported since publication in 2022.
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