Gestational diabetes mellitus placentas exhibit epimutations at placental development genes

Laetitia P. Meyrueix, Raad Gharaibeh, Jing Xue, Cory Brouwer, Corbin Jones, Linda Adair, Shane A. Norris & Folami Ideraabdullah
Gestational diabetes mellitus (GDM) is a maternal metabolic disorder that perturbs placental development and increases the risk of offspring short- and long-term metabolic disorders. The mechanisms by which GDM impairs placental development remain poorly understood. Here, we defined the DNA methylome of GDM placentas and determined whether GDM perturbs methylation at genes important for placental development. We conducted an epigenome-wide association study of 42 placentas from pregnancies in the South African Soweto First 1000 days...
1 citation reported since publication in 2022.
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