A pair of novel trimeric indole alkaloid enantiomers [(±)-8], five new bisindole alkaloids [4–7 and (±)-9], and three pairs of new monomeric indole alkaloid enantiomers [(±)-1–(±)-3], together with seven known alkaloids (10–16), were isolated from the bark of Acacia confusa. Their structures were determined on the basis of spectroscopic methods, especially by NMR data analyses combined with single-crystal X-ray diffraction and electronic circular dichroism analyses. Compounds 4 and 11–16 exhibited significant antinociceptive activities in an...