Epigenome-wide association studies of occupational exposure to benzene and formaldehyde

Rachael V. Phillips, Linqing Wei, Andres Cardenas, Alan E. Hubbard, Cliona M. McHale, Roel Vermeulen, Hu Wei, Martyn T. Smith, Luoping Zhang, Qing Lan & Nathaniel Rothman
Sufficient evidence supports a relationship between certain myeloid neoplasms and exposure to benzene or formaldehyde. DNA methylation could underlie benzene- and formaldehyde-induced health outcomes, but data in exposed human populations are limited. We conducted two cross-sectional epigenome-wide association studies (EWAS), one in workers exposed to benzene and another in workers exposed to formaldehyde. Using HumanMethylation450 BeadChips, we investigated differences in blood cell DNA methylation among 50 benzene-exposed subjects and 48 controls, and among 31 formaldehyde-exposed...
1 citation reported since publication in 2022.
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