Novel hybrid molecules based on disulfides and 1,2,4-triazole as antiproliferative agentsJunjie Li, Yang Liu, Yanle Men, Zijian Li, Yanping Shi, Xuguang Liu & Baoquan Chen
A series of novel hybrid molecules based on disulfides and 1,2,4-triazole were synthesized, and the structures of the resulting compounds (7a–7g, 8a–8g and 9a–9g) were confirmed by their IR, 1H NMR, 13C NMR and HR-ESI-MS spectroscopic data. The in vitro antiproliferative activity of the tested compounds on human cancer cells A549, Hela, SMMC-7721, and normal cells L929 was determined by CCK-8 assay. The obtained data revealed that most of the tested compounds showed some degrees...
1 citation reported since publication in 2022.
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