Sample size calculation and timing of dose selection in an adaptive multiple-dose clinical trial

Liji Shen, Jin Zhang & Paul DeLucca
In a two-stage design for multiple-dose clinical trial, a dose that has the highest observed response rate is often chosen to carry to the next stage, then to compare against the control group. The observed response rate could overestimate the true response rate of the selected dose. If it is used to compare with the response rate of the control group without any adjustment, the Type I error of this statistical inference will not be...
1 citation reported since publication in 2022.
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