Interstitial lung disease associated with anti-HER2 anti-body drug conjugates: results from clinical trials and the WHO's pharmacovigilance database

Zhuo Ma, Yi Zhang, Min Zhu, Lin Feng, Yuhui Zhang & Zhuoling An
Interstitial lung disease (ILD) events associated with anti-human epidermal growth factor receptor 2 (HER2) antibody-drug conjugates (ADCs) have aroused wide attention. In meta-analysis, we systematically reviewed literatures, and the outcomes were the proportion and risk of ILD related to anti-HER2 ADCs. A disproportionality analysis based on data from VigiBase was conducted to characterize the main features of anti-HER2 ADC-related ILD/pneumonitis. Two hundred and forty-five all-grade and 47 grade ≥ 3 ILD events with the proportion...
1 citation reported since publication in 2022.
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