Novel mycoplasma nucleomodulin MbovP475 decreased cell viability by regulating expression of CRYAB and MCF2L2

Gang Zhao, Doukun Lu, Shujuan Wang, Hui Zhang, Xifang Zhu, Zhiyu Hao, Ali Dawood, Yingyu Chen, Elise Schieck, Changmin Hu, Xi Chen, Liguo Yang & Aizhen Guo
Nucleomodulins are secreted bacterial proteins whose molecular targets are located in host cell nuclei. They are gaining attention as critical virulence factors that either modify the epigenetics of host cells or directly regulate host gene expression. Mycoplasma bovis is a major veterinary pathogen that secretes several potential virulence factors. The aim of this study was to determine whether any of their secreted proteins might function as nucleomodulins. After an initial in silico screening, the nuclear...
1 citation reported since publication in 2022.
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