USP38 inhibits colorectal cancer cell proliferation and migration via downregulating HMX3 ubiquitylation

Jun Wang, Yongxing Gu, Xueqin Yan, Jie Zhang & Yong Ding
Accumulating evidence has shown that H6 Family Homeobox 3 (HMX3) plays a crucial role in nervous system regulation. However, the regulatory mechanism of HMX3 in colorectal cancer (CRC) has seldom been studied. Herein, HMX3 was significantly downregulated in CRC, as demonstrated by qRT-PCR and WB analysis on clinical samples and a panel of cell lines. Besides, it was found that the expression of HMX3 was negatively correlated with survival of CRC patients. The functional analyses...
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