Sasanquasaponin inhibited epithelial to mesenchymal transition in prostate cancer by regulating the PI3K/Akt/mTOR and Smad pathways

Wenfeng Li, Yuanshen Mao, Bao Hua, Xin Gu, Chao Lu, Bin Xu & Weixin Pan
Sasanquasaponin (SQS) is a commonly used traditional Chinese medicine proved to have a wide range of pharmacological functions. The objective of this study is to explore the effect and underlying mechanism of SQS in the treatment of prostate cancer (PC). PC cell lines (22Rv1 and PC-3) were treated with SQS (0, 0.5, 1, 2, and 4 μM) for 12 or 24 h. The viability of cells was evaluated, while the mRNA and protein levels of...
1 citation reported since publication in 2022.
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