Association of Paraoxonase-1 Genotype and Phenotype with Angiogram Positive Coronary Artery Disease

Sara Saffar Soflaei, Mojtaba Baktashian, Kiana Hosseinpour Moghaddam, Maryam Saberi-Karimian, Negin Kosari, Seyed Mohammad Hashemi, Mohsen Mouhebati, Mahsa Amini, Mashallah Dehghani, Habibollah Esmaily, Mahmoud Ebrahimi, Homa Falsoleiman, Abolfazl Nosrati-Tirkani, Fatemeh Sadabadi, Gordon A. Ferns, Mansoor Salehi, Alireza Pasdar & Majid Ghayour-Mobarhan
Abstract Background It has been shown that increased serum PON1 levels are protective against several disorders. Several single nucleotide polymorphisms (SNPs) of the PON1 gene have been reported to be associated with serum enzyme protein levels and activity. Objective To investigate the association of SNPs of PON1 and serum paraoxonase activity with coronary artery disease (CAD). Methods A total of 601 unrelated patients who underwent coronary angiography including those who had >50% stenosis (N=266) and...
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