Efficient enzymatic hydrolysis of Protogracillin for clean preparation of Prosapogenin A by response surface methodology optimization

Haicheng Xie, Le Zhang, Shunli Jing, Jinwei Zhou, Qing Wu, Yaya Yang, Yufei Chen, Chengyu Yang, Guohua Xia, Yuping Shen & Huan Yang
Prosapogenin A (also known as Progenin III and polyphyllin V), a secondary steroidal saponin in Dioscorea zingiberensis tubers, has more superior pharmacological activities than its primary form Protogracillin. Conventional preparation methods, such as column chromatography, and acidic hydrolysis, are of very low efficiency and limited scale due to tedious procedures and large consumption of organic solvent. This study aims to establish a convenient method for efficiently obtaining Prosapogenin A by enzymatic hydrolysis of abundant Protogracillin...
1 citation reported since publication in 2022.
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