Additional file 13 of An integrated in silico-in vitro approach for identifying therapeutic targets against osteoarthritis

Raphaëlle Lesage, Mauricio N. Ferrao Blanco, Roberto Narcisi, Tim Welting, Gerjo J. V. M. van Osch & Liesbet Geris
Additional file 13: Fig. S4. Decision tree summarizing the variable updating scheme employed in algorithm to simulate the in silico chondrocyte. Each biological component is represented by the gene expression level (slow variable) and the protein activity potential (fast variable). Variables are updated based on the rules stored in the model’s equations. First, fast variables are updated in random order, when a pseudo-stable state is reached and that all fast variables have been updated, the...
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