Additional file 14 of An integrated in silico-in vitro approach for identifying therapeutic targets against osteoarthritis

Raphaëlle Lesage, Mauricio N. Ferrao Blanco, Roberto Narcisi, Tim Welting, Gerjo J. V. M. van Osch & Liesbet Geris
Additional file 14: Fig. S5. Illustration of the algorithm for the asynchronous updating of variables with a simplified (3 nodes) example network. The network represents interactions happening in one of the subnetworks (protein= fast reactions or genetic = slow reactions). Inhibitions are represented in red and activations are in black. The mathematical rules corresponding to the network are displayed. If the rules result in a value lower than 0 (resp. higher than 1), the value...
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