Genetic diversity of Trypanosoma cruzi strains isolated from chronic chagasic patients and non-human hosts in the state of São Paulo, Brazil
Thiago Kury Moreno de Souza, Elizabeth Visone Nunes Westphalen, Sansão da Rocha Westphalen, Helena Hilomi Taniguchi, Carlos Roberto Elias, Gabriela Motoie, Ricardo Gava, Vera Lucia Pereira-Chioccola, Christina Terra Gallafrio Novaes, Noêmia Barbosa Carvalho, Edimar Alcides Bocchi, Fátima das Dores da Cruz, Mussya Cisotto Rocha, Samuel Katsuyuki Shinjo, Maria Aparecida Shikanai-Yasuda, Paola Andrea Ortiz, Marta Maria Geraldes Teixeira & José Eduardo Tolezano
BACKGROUND Trypanosoma cruzi shows an exuberant genetic diversity. Currently, seven phylogenetic lineages, called discrete typing units (DTUs), are recognised: TcI-TcVI and Tcbat. Despite advances in studies on T. cruzi and its populations, there is no consensus regarding its heterogeneity. OBJECTIVES This study aimed to perform molecular characterisation of T. cruzi strains, isolated in the state of São Paulo, to identify the DTUs involved and evaluate their genetic diversity. METHODS T. cruzi strains were isolated from...
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