Additional file 1 of mTORC1-c-Myc pathway rewires methionine metabolism for HCC progression through suppressing SIRT4 mediated ADP ribosylation of MAT2A

Liang Zhao, Huizhao Su, Xiaomeng Liu, Hongquan Wang, Yukuan Feng, Yan Wang, Haiqiang Chen, Luo Dai, Shihui Lai, Siqi Xu, Chong Li, Jihui Hao & Bo Tang
Additional file 1. Additional methods. Fig. S1. mTOR senses the availability of methionine. Fig. S2. mTORC1 signaling pathway mediated Myc expression to promote HCC tumorigenesis. Fig. S3. Negative correlation of MYC and SIRT4 expression. Fig. S4. Myc regulates SIRT4 stability through proteasome degradation. Fig. S5. Characterization of the interaction between SIRT4 and TRIM32. Fig. S6. SIRT4 suppresses Myc promoted HCC tumorigenesis. Fig. S7. The effect of SIRT4 on histone methylation through regulating methionine metabolism. Fig....
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