Spleen-based proteogenomics reveals that Escherichia coli infection induces activation of phagosome maturation pathway in chicken

Jiahui Shi, Songhao Jiang, Qiang Wang, Jilin Dong, Huiming Zhu, Peijia Wang, Shuhong Meng, Zhenpeng Zhang, Lei Chang, Guibin Wang, Xiaoqin Xu, Ping Xu & Yao Zhang
Avian pathogenic Escherichia coli (APEC) leads to economic losses in poultry industry and is also a threat to human health. Various strategies were used for searching virulence factors, while little is known about the mechanism by which APEC survives in host or is eliminated by host. Thus, chicken colibacillosis model was constructed by intraperitoneally injecting E. coli O78 in this study, then the protein dynamic expression of spleen was characterized at different post-infection times by...
1 citation reported since publication in 2022.
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