Induction of Significant Neutralizing Antibodies against SARS-CoV-2 by a Highly Attenuated Pangolin Coronavirus Variant with a 104nt Deletion at the 3'-UTR
Shanshan Lu, Shengdong Luo, Chang Liu, Muli Li, Xiaoping An, Mengzhe Li, Jun Hou, Huahao Fan, Panyong Mao, Yigang Tong & Lihua Song
SARS-CoV-2 related coronaviruses (SARS-CoV-2r) from Guangdong and Guangxi pangolins have been implicated in the emergence of SARS-CoV-2 and future pandemics. We previously reported the culture of a SARS-CoV-2r GX_P2V from Guangxi pangolins. Here we report the GX_P2V isolate rapidly adapted to Vero cells by acquiring two genomic mutations: an alanine to valine substitution in the nucleoprotein and a 104-nucleotide deletion in the hypervariable region (HVR) of the 3′-terminus untranslated region (3′-UTR). We further report the...
1 citation reported since publication in 2022.
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