New steroids from the pericarps of Datura metel L

Yan Liu, Yuan Liu, Hai-dan Zou, Yong-qiang Zhou, Juan Pan, Wei Guan, Adnan Mohammed Algradi, Bing-you Yang & Hai-xue Kuang
Three new steroids (1–3) and 13 reported analogs (4–16) were extracted from Datura metel L. pericarps. Structure analysis of these extracted compounds was performed by 1 D-NMR and 2 D-NMR spectroscopy, and their spectra were compared with those of similar compounds previously described in the literature. The extracted steroids (1–3) and known compounds (4–16) were evaluated for anti-inflammatory activity against LPS-activated RAW 264.7 cells. Compounds 5, 7, 9, 12 and 15 showed potential anti-inflammatory activity...
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