Identification and quantitative analysis of bioactive components from Potentilla kleiniana Wight et Arn with anti HIV-1 proteases activity

Yong Qiang Zhou, Su Mei Li, Xin Wei, Xin Yang, Jun Wei Xiao, Bo Wen Pan, Shou Xia Xie, Ying Zhou, Jian Yang & Ying Wei
Potentilla kleiniana Wight et Arn(PK, ‘Wu Pi Feng’ in Chinese) was recorded as Miao ethnic medicine for treatment of fever, cough, ulcer, and erysipelas for thousands years. This study aimed to evaluate the antiviral activity of four PK extracts and seven compounds by using HIV-1 protease (HIV-1 PR). In addition, Ultra-High Performance Liquid Chromatography and High Resolution Mass Spectrometry (UPLC-HRMS) was employed to identify the bioactive components. The toxicity assessment of the extracts was done...
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