Exploration of the potential neuroprotective compounds targeting GluN1-GluN2B NMDA receptors

Meixi He, Yi Wang, Xiaozhe Zhang & Lihua Zhang
The N-methyl-d-aspartic acid (NMDA) receptors belongs to the family of ionotropic glutamate receptors, which could mediate most excitatory synaptic transmission in the brain. It is interesting to know if some available drugs have regulatory effects on the NMDARs. Herein, the present study reports the discovery of drugs targeting NMDAR using virtual screening. In this study, talniflumate with the EC50 value at 61.49 nM was successfully screened. The interaction analysis of this compound was further explored...
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