Synthesis and antimicrobial activity of aminoalkyl resveratrol derivatives inspired by cationic peptides

Rubén Cebrián, Ricardo Lucas, María Victoria Fernández-Cantos, Koen Slot, Pablo Peñalver, Marta Martínez-García, Antonio Párraga-Leo, María Violante de Paz, Federico García, Oscar P. Kuipers & Juan Carlos Morales
Antimicrobial resistance is a global concern, far from being resolved. The need of new drugs against new targets is imminent. In this work, we present a family of aminoalkyl resveratrol derivatives with antibacterial activity inspired by the properties of cationic amphipathic antimicrobial peptides. Surprisingly, the newly designed molecules display modest activity against aerobically growing bacteria but show surprisingly good antimicrobial activity against anaerobic bacteria (Gram-negative and Gram-positive) suggesting specificity towards this bacterial group. Preliminary studies...
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