Identification of major hub genes involved in high-fat diet-induced obese visceral adipose tissue based on bioinformatics approach

Yu Jiang, Rui Zhang, Jia-Qi Guo, Ling-Lin Qian, Jing-Jing Ji, Ya Wu, Zhen-Jun Ji, Zi-Wei Yang, Yao Zhang, Xi Chen, Gen-Shan Ma & Yu-Yu Yao
High-fat diet (HFD) can cause obesity, inducing dysregulation of the visceral adipose tissue (VAT). This study aimed to explore potential biological pathways and hub genes involved in obese VAT, and for that, bioinformatic analysis of multiple datasets was performed. The expression profiles (GSE30247, GSE167311 and GSE79434) were downloaded from Gene Expression Omnibus. Overlapping differentially expressed genes (ODEGs) between normal diet and HFD groups in GSE30247 and GSE167311 were selected to run protein–protein interaction network, GO...
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