Agrochemical-mediated cardiotoxicity in zebrafish embryos/larvae: What we do and where we go

Yang Yang, Yue Tao, Zixu Li, Yunhe Cui, Jinzhu Zhang & Ying Zhang
The massive application of agrochemicals and associated environmental residues greatly threaten human health. Cardiac dysfunction, as a major contributing factor to human mortality, is increasingly reported in health risk assessments to be associated with agrochemical exposure. In this mini-review, we summarize the cardiotoxicity of various agrochemicals including herbicides, insecticides, fungicides, and acaricides on zebrafish embryos/larvae and systematically discuss the role of cardiac development-related pathway disorders, imbalance in Ca2+ homeostasis, mitochondrial dysfunction, and general negative effects...
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